Most of these studies are about a month. Have you ever done the cold shower after your sauna? And so I just go into like crazy mode and I like I like somehow like crawled from our bedroom all the way out to the living room. No wise. Yeah, it was terrible. And I think that doing the sauna is making you more resilient against against infection like there. So for you personally, if you had the option, would you do it once a week? That's what I need. And I freak out and I scream. And it's like the first time I ever went camping and it was like snow camping. You don't use this on those occasion. And people were getting sick. So three grams, three grams. There's so fucking stupid, because you've got to realize these people that are writing these lists, these are not experts. But you know that I am taking zinc is also a positive ion. Learn more about Dr. Rhonda Patrick. I was just like, you know, he's vomiting. The water much work like ice. Do you pour water on your rocks? But, you know, I'm . Yeah. But anyways, you give them this amyloid beta and after like a couple of days, they become paralyzed or they're like laying in their little petri dish plate on the cold food. But for thousands the the the what the they indicated as the tolerable upper intake. OK, don't hold me to the month, give me some month or two months. So if you do it like before symptoms, like there's a better, you know, outcome as well. I was doing Hot Bath and we could talk about that. And then it came back like a couple of months later or like a few months later back when we were home. That's great. When you buy hardwood, they saw the wood, they take the pellets from that sawdust and they compress that sawdust and make these pellets. Four percent of patients that died from covid-19 were vitamin D ERSEK four percent, only four percent were vitamin D sufficient. Corruption in these in Tarzana. I guess maybe that that's why I've even heard people dismiss vitamin C saying that your body only absorbs a certain amount. So there's studies there's been some large scale and genetic studies that have found that Asians, about 20 percent of Asians have a basically a nucleotide change in a gene that encodes for a protease that's involved in this, you know, basically in allowing this virus to get into the cell. Like his frequent podcast guest Dr. Rhonda Patrick, Rogan is a big fan of vitamin D3. They were around for three years already. I mean it's like just from that alone. But after I graduated, I went to work at the Salt Institute for Biological Sciences and the way I was working in an aging lab. Certain things will spike it worse than others. Well, is this I mean, this is decades ago. You know, it's important. So I think, you know, there's there's lots of avenues for, you know, therapeutics. Vitamin D is different than vitamin C because it is fat-soluble and can be stored by the body. I'm just taking 5000 right now because that's like I could buy the five. And if they had and they were 20 times less likely to have critical like a critical form of covid-19. Because that's really the easiest thing. There's something mood enhancing. It's a not a natural human inclination. And I think that that I think that eventually there's going to be therapeutics that are identified, you know, not multiple ones maybe. So it does make sense, but I don't. She has done extensive research on aging, metabolism, nutrition, and cancer. Well, oh, no. But they're also stressed out and they have anxiety in particular, if their bills are piling up and they have no income through. Yeah. Interesting. So it's a lifelong thing. You take three grams, you get it to 220. I have I have my son. But that's kind of the concern. 6 hours? I will say this like my one of my friends, she's a she's an M.D. And like, I like he's a tech guy. It's just like this. She has dedicated her research career to finding proactive and preventive solutions to aging and longevity. So we got that literally. OK, so there we go. She had discussed the optimal dosage on both her website and a variety of different podcasts. What, what's this headline. It's routinely used for sepsis, like friends of mine, you know, use that use it for treating sepsis. I know. I did. Yeah. I think. Do you know about these red light machines that people stand in front of? I love it. I really hope that. It yes. You're having your discs or protruding and your disc. Also, as the oldest continuously operating distillery in America, Buffalo Trace Distillery has experienced more than its fair share of adversity floods, fires, wars, recessions and prohibition. Isn't that isn't CBD supposed to like also be like calming one. The bottom line is on honesty, that's intravenous. I mean, I don't even know he's been fucked up for, like, a really bad. Cause there's so many studies published. That makes sense, but to all be asymptomatic? Providing anti-inflammatory effects It's such a strange virus. We have some here. So so then I found out I was pregnant and so I was like, OK, well, I can't go back to the dentist. Right. Oh can I get a trampoline. She includes a daily dose of 5,000iu each day. Do you have a song in your house. W what is, what is the top of this. I mean, you'd think she'd had Kovik. And the red light. I remember like after show like you chew gum right. Louis Simmons invented it because he had a herniated disc and the doctors are telling him, hey, we have to operate on you because you have this compressed disc. But there's another one that causes dental decay. Under normal circumstances, this is very important. And I want to I want to have an honest take on it. But the fact that it has been shown to to treat to improve sepsis outcomes in multiple, you know, studies. It's more than that the first time you come along so. I mean, how so? But but I was like I started out the conversation. So the xylitol gum somehow. So I do that. So my tongue slides. So it's like, yeah, it's hard to balance is very difficult. He wants to party all day, every day. I'm glad you brought up hot baths, because that's something that I wanted to cover before we got off track. There's I think there's a lot there's a lot stronger there's much more research on not only Driss on us, but in Finland, they take they take the sauna dry sauna has like these hot rocks and they pour water on top of the hot rock. Yeah. And then we're going to you know, we're doing some other things, vitamin C, three grams, three times a day, and then vitamin B one can talk about that thiamin as well. And so he had to go to the hospital. But the question is, is like, you know, there's there's homeostatic processes in these cells and stuff and so is it. Gum all the way up until anywhere between the child, you know, the baby being six months and there were some studies that went out like a year, and then they met the the researchers measured the oral bacteria of the toddlers. Would it wouldn't be hot enough to kill it. So I think, you know, for for people that don't have access to a sauna, that hot baths absolutely are a good a model for heat stress. There's been seasons, right? And that's how a lot of people start. That makes a huge impact on my son and his sleep cycle, like because children are really sensitive to light because they don't have like cataracts and stuff. Transcript of #1474 - Dr. Rhonda Patrick | Happy Scribe Dr. Rhonda Patrick is a Ph.D. in biomedical science and expert on nutritional health. So I kind of with his help, I've helped him design an open arm trial, very small for his patients where where where he is going to be giving them fifty thousand. So you can see 10 grams is like in 10 grams is 10000 milligrams. Yeah. The medical model used by the United States Endocrine Society covers a wide range of vitamin D functions as opposed to just bones. Right. I mean, it's like naptime is like what can I get work done or it could take a shower. So I was going to bed really late at night and I was just always tired. That company got a lot of shit for their claims. Is there any speculation as to why these large groups there was another one that was a meatpacking plant where most of the people were asymptomatic as well. And then on top of that, even though it's only 105 degrees, your body is heating up. Researchers believe the particular antibody, which has been found in other Lomez as well, can be injected into an uninfected individual to protect them from getting infected with the new coronavirus. Popcorn will spike it really bad. And those people are more likely to die from respiratory infections just based on that gene alone. It almost seems like there's multiple viruses. They're not just making whiskey. So what is the benefit of it being that hot, though? For this reason, Dr. Rhonda Patrick is extremely important. So, you know, and then there was another study that was like some other messed up diabetic animal model where the vitamin D actually didn't increase the ace to receptor, but it increased what's called soluble ace to which is in like it's in the periphery. And elderly people are more zinc deficiencies not really common in the U.S. This strategy that you guys have, you're not adjusting and adapting. I'm gonna have to go over this one again and take notes. To get an outcome. I have the cash, have folks cash out the easiest way to send money between your friends and family without having to hold that dirty paper and when you download the cash app. So that's the thing we got to be careful about. But that's interesting because your neutrophils, your neutrophils generate hydrogen peroxide. And I was like, this is amazing. I think it's a really good hypothesis. It's just so awful for them, terrible for you. Like I was hot as fuck, right? So what happens when you take them? Oh, can I, can I exploit rock pools. It's hard to tell because I do so much shit. Ropin. They're not just like, boom, full stop going to, like, increase something when everything's normal. I don't even know if it's necessary, honestly, to be honest, because again, it's a therapeutic, you know, treatment. The full extent of vitamin's D impact has yet to be fully understoodnearly every cell and tissue in our body has vitamin D receptors (proteins that bind to vitamin D); and in its active form, vitamin D can interact with the vast majority of the body's cells. It's like what happens when you go into menopause. And so your heart rate doesn't increase as much like over time. So are you a fan of Kombucha, do you. It's intense. Like someone needs to be naked somewhere. So clearly, socioeconomic status and other health factors are playing a role. There's more meta analysis. Teeter has two things that are really cool. But the cold shock, you ask me, cold shock proteins, that that hasn't really been measured in humans. What factor do you think, like when we're talking about Centage before one of the things this is a respiratory disease and this is something where you're breathing in these particles. I feel for people that are in that state where they realize that they're not they're not happy, they're not happy with their own performance and aren't happy with their life. Right. Autism. Yes, yes. Shame on me. But so you go and you do these different they have all these different types and I don't remember. All we're hearing is shelter in place, wear a mask, don't touch anybody. No, I have. I don't I don't have that same perspective. Learn more about Dr. Rhonda Patrick. It would be amazing to have a sauna outside sauna that's right next to a frozen lake. So there's there's benefits with these with the infrared personally. Remember, that's the big lady that was showing you earlier. Well, Jordan Peterson just went through all this and literally had a benthos. But he was like all of a sudden, like the first time he had it, he was just like, pain. I mean, so far the maximum I've seen measured is like 70 times that your blood can get 70 times 200 say I was like, wow, 18000 or 17000 or something. Like how is your immune system shaped by what your there's your diet that's included in it, your vitamin D status, your you know, there's there's you know, the other interesting thing and there's been no studies with sars-cov-2, but there have been influenza studies showing that viral dose. I get a flare up and it's like I'm sure I'm out. So why do you take five. I mean, I'm reading all these publications. Cloudy all the time. No you can't. And it's it's you know, we're slowly getting to the to the point where we're going to have more and more where it's just like you have to have easy access. It was actually lack of sleep. So with that that lady right there in that image, she's holding onto those handles. There was a study that was over twenty five randomized controlled trials. She didn't. But they're in there for like an hour, you know, and they're getting they raised their core body temperature. So I have I do the Philipps you wear at like five o'clock, all the lights in our house go red. Yeah. less vitamin D = more immigrant mentality, Apparently this "study" is completely garbage. It's for the lung function in the respiratory function. But here's the other interesting thing is that if you don't take it multiple times throughout the day, you only take it once. And all the, you know, studies that have shown that on top of that, I mean, that's like it's it's super intense. Health and safety is on the top of everyone's mind right now. That game we've been doing as Eilerts on it. But what just, you know, doing some some reading about like, why are people's immune systems so different? What is the one I drink. Did it? To fully understand how many people living in the world are vitamin D deficient, this phrase must be defined. COVID-19 Q&A #1 with Rhonda Patrick, Ph.D. More evidence having poor vitamin D status before infection increases COVID-19 severity and death risk. That's going to, like, aggravate it. I think focusing on on, you know, lifestyle factors that you can, you know, possibly modern. It's not like, you know, drugs. So great. That's Louis right there. But but it will prevent you from spreading it, you know. She typically takes 2 of the Nordic Naturals ProOmega 2000 and 4 of the Nordic Naturals Omega-3 Phospholipids daily. Generally speaking, one thousand I use will raise your blood levels by about five nanograms per minute. It is. And I was like, yeah, I'm going to do this. Like some of those numbers. A lot of a lot of people are sleep deprived, so. We drink it all the time. Yell out the window, happy birthday. That's big. I'm just so thankful that it's not as bad, right, I mean, I really am thankful as well, but I think our government needs to make an adjustment. The other thing that happens is the antibody binds to the virus, doesn't neutralize it, but it like makes this crazy immune complex that, like, activates your immune system to just go haywire and it causes all sorts of pathology. To Legal Zoom, whether you need a last will or a living trust or advance health care directive, you can do it all legal zoom. I remember I was on a plane once and there was this guy behind me and he was a kind of a heavy fellow and he was, he was really snoring loud. Yeah. So that I intravenous vitamin C, I think it had to be 12 and it should be twelve shots give you an awesome little boost. I'll find it. I really think you are awesome to talk to. I like the ginger lemon a lot and I like this one. So it shows you like how much sleep you got, how much recovery you recoveries out and what you need even tell you, you know, hey, you should go to bed since you'd be getting up at six o'clock in the morning, you should go to bed by 10:00 tonight. So that's so bad. I don't know what the characters are now, but I'm doing a small number of characters and I'm just sharing one study. I mean, the bigger your audience is, the more you get that. And in fact, because the zinc is bound to fight weight, it's less bioavailable. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc. So the bottom line here is that. The study involved an investigation of supplementation using prophylactic vitamin D supplements. So you take 200 milligrams. That's like my shower time now. Low levels are linked to cancer, diabetes and cardiovascular disease. It's in a dark bottle. Yeah. You can. There are. And I totally stopped having for the most part, Dan says, yeah, like I went through one episode where what happens when someone has a nightmare is like if someone else in the sharing the bed with you, like, tries to stop you or help, like because I'm still asleep, I'm not aware that that's my husband doing that. Oh, he used to be out here. Essentially its taking a blood test every few weeks to see how Vitamin D is impacting your levels positively or negatively and slowly over time working you into a range ~30-50ng. That's a lot of times you think it's that area, but it's not. Right. The thing about the sauna, 210 degrees to one of the things that it was happening to me, I was getting headaches and my throat was burning like the next I was coughing a lot like and I was like I think I'm fucking up the actual tissue in my throat. And like I said, I was like trying to impress Rick. Yeah. Rhondas optimal dosage is 5,000iu daily. Let's quarantine the people who are sick. And in this I want to call it sciatica. Have you done those ice? When I hit the hill, I'm like, wow, this is crazy. Look, I have conversations with good friends all the time and even on the podcast where I disagree with them. So the upper the tolerable upper intake has been set by the Nutrition Board, the Institute of Medicine, to be 4000 hours a day. I'm sorry. Did, you know, like between 50 to 80 percent of the U.S. population has it like at least by the time they're like an adult has it permanently or so it's a it's a herpes virus. I know it's hard though. The people with low baseline vitamin D levels. But after a week, people that had the heat treatment, local heat treatment, had almost 40 percent less muscle atrophy and shoot in animal studies. And once you go above that, like when you if you take 500 milligrams of vitamin C orally, you start to excrete a lot in urine. There was less this. Have you ever measured your heart rate during it? Absolutely. And this is why it basically so it it changes your immune system. When it's cold and rainy with short days, I don't feel nearly as happy. Like the way they do it. #1474 - Dr. Rhonda Patrick The Joe Rogan Experience 125 Clips. They're measuring that rectally. So here's the thing with that. It's like this like and now I'm, I'm guarantee you it's just pure form and all kinds of things need to do more. I mean, there's lots of changes that occur. Hiking trails and paths allowing distancing horsetrading singles jogging and running. Vitamin D is then converted by the body into calcitriol, a steroid hormone. I know that that I was mentioning that TB vaccine. I was I was searching for that the other day. That's what it looks like. And they want to just they want to shoot people down, make people feel bad and just don't. The Joe Rogan Experience #1178 - Dr. Rhonda Patrick. Like what does that do for you, you know, supposed to jack up your immune system. And because I was like, is that like an Ignacia thing? I know. And from what I understand, that this is a vulnerable virus in terms of the temperature that it can survive in.

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